Novel Antihypertensive Therapies: Renal Sympathetic Nerve Ablation and Carotid Baroreceptor Stimulation

被引:7
|
作者
Grassi, Guido [1 ,2 ,3 ]
Seravalle, Gino [2 ]
Brambilla, Gianmaria [2 ]
Bombelli, Michele [2 ]
Dell'Oro, Raffaella [2 ]
Gronda, Edoardo [3 ]
Mancia, Giuseppe [2 ]
机构
[1] Univ Milano Bicocca, San Gerardo Hosp, Med Clin, I-20052 Monza, MI, Italy
[2] Univ Milano Bicocca, Dept Clin Med & Prevent, Med Clin, I-20052 Monza, MI, Italy
[3] Ist Ric & Cura Carattere Sci Multimed, Milan, Italy
关键词
Hypertension; Blood pressure; Resistant hypertension; Interventions; Renal denervation; Carotid baroreceptor stimulation; End-organ damage; Insulin; Side effects; BAROREFLEX ACTIVATION THERAPY; RESISTANT HYPERTENSION; BLOOD-PRESSURE; DOUBLE-BLIND; DENERVATION; SPIRONOLACTONE;
D O I
10.1007/s11906-012-0312-5
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Therapeutic interventions aimed at reducing high blood pressure still encompass a number of difficulties and limitations. This is the case particularly in resistant hypertension, i.e. a condition characterized by a very high cardiovascular risk. Carotid baroreceptor stimulation and renal sympathetic nerves ablation represent new approaches in the treatment of this condition. This paper will provide a comparison of the effects of the two procedures, highlighting their effects on blood pressure, metabolic profile, target organ damage, safety and tolerability profile.
引用
收藏
页码:567 / 572
页数:6
相关论文
共 50 条
  • [31] Renal Nerve Stimulation as Procedural End Point for Renal Sympathetic Denervation
    Hoogerwaard, Annemiek F.
    de Jong, Mark R.
    Elvan, Arif
    CURRENT HYPERTENSION REPORTS, 2018, 20 (03)
  • [32] Renal sympathetic nerve ablation for treatment-resistant hypertension
    Krum, Henry
    Schlaich, Markus
    Sobotka, Paul
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 76 (04) : 495 - 503
  • [33] Renal Sympathetic Nerve Ablation: The New Frontier in the Treatment of Hypertension
    Markus P. Schlaich
    Henry Krum
    Paul A. Sobotka
    Current Hypertension Reports, 2010, 12 : 39 - 46
  • [34] Renal Sympathetic Nerve Ablation: The New Frontier in the Treatment of Hypertension
    Schlaich, Markus P.
    Krum, Henry
    Sobotka, Paul A.
    CURRENT HYPERTENSION REPORTS, 2010, 12 (01) : 39 - 46
  • [35] Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension.
    Schlaich, Markus P.
    Sobotka, Paul A.
    Krum, Henry
    Lambert, Elisabeth
    Esler, Murray D.
    NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (09): : 932 - 934
  • [36] Renal sympathetic nerve ablation for the management of resistant hypertension: an update
    Thorp, Alicia A.
    Larsen, Robyn N.
    Schlaich, Markus P.
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2013, 22 (06): : 607 - 614
  • [37] RENAL SYMPATHETIC-NERVE DISCHARGE AND RENAL BLOOD-FLOW AS INFLUENCED BY BARORECEPTOR AND EMOTIONAL STIMULI
    KIRCHHEIM, H
    GROSS, R
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1978, : R33 - R33
  • [38] Chaotic behavior of renal sympathetic nerve activity: effect of baroreceptor denervation and cardiac failure
    DiBona, GF
    Jones, SY
    Sawin, LL
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, 279 (03) : F491 - F501
  • [39] RENAL EFFECTS OF ELECTRICAL STIMULATION OF CAROTID SINUS NERVE
    MICHAELI.LL
    GILMORE, JP
    SURGERY, 1969, 65 (05) : 797 - &
  • [40] Unilateral carotid sinus stimulation and muscle sympathetic nerve activity in man
    Williamson, JW
    Muzi, M
    Ebert, TJ
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1996, 28 (07): : 815 - 821