Cytotoxic sesquiterpene lactones from Artemisia myriantha

被引：10

作者：

Zan, Ke ^{[2
]}

Chen, Xiao-Qing ^{[3
]}

Zhao, Ming-Bo ^{[1
]}

Jiang, Yong ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China

[2] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China

[3] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2020年 / 37卷

基金：

中国国家自然科学基金;

关键词：

Artemisia myriantha Wall. ex Bess; Asteraceae; Sesquiterpene lactones; Cytotoxic activity; DIMERIC GUAIANOLIDES; ARGYI;

D O I：

10.1016/j.phytol.2020.03.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical exploration of Artemisia myriantha Wall. ex Bess (Asteraceae) aerial parts afforded one new seco-guaianolide (1) and one new germacranolide (2). Structure elucidation of the new compounds was un-ambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. The two new compounds exhibited in vitro strong cytotoxic activities against human cancer cell lines HCT-8 with IC50 values of 0.76 and 0.28 mu M, respectively.

引用

页码：33 / 36

页数：4

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