Cytotoxic sesquiterpene lactones from Artemisia myriantha

被引：10
|
作者：
Zan, Ke [2 ]
Chen, Xiao-Qing [3 ]
Zhao, Ming-Bo [1 ]
Jiang, Yong [1 ]
Tu, Peng-Fei [1 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China
[2] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China
[3] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2020年 / 37卷
基金：
中国国家自然科学基金;
关键词：
Artemisia myriantha Wall. ex Bess; Asteraceae; Sesquiterpene lactones; Cytotoxic activity; DIMERIC GUAIANOLIDES; ARGYI;
D O I：
10.1016/j.phytol.2020.03.009
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Chemical exploration of Artemisia myriantha Wall. ex Bess (Asteraceae) aerial parts afforded one new seco-guaianolide (1) and one new germacranolide (2). Structure elucidation of the new compounds was un-ambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. The two new compounds exhibited in vitro strong cytotoxic activities against human cancer cell lines HCT-8 with IC50 values of 0.76 and 0.28 mu M, respectively.
引用
收藏
页码：33 / 36
页数：4
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