Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives

被引：3
|
作者：
Saundane, Anand R. [1 ]
Verma, Vaijinath A. [2 ]
Katkar, Vijaykumar T. [1 ]
机构：
[1] Gulbarga Univ, Dept Postgrad Studies & Res Chem, Gulbarga 585106, India
[2] Shri Prabhu Arts Sci & JM Bohra Commerce Degree C, Shorapur 585224, Karnataka, India
来源：
JOURNAL OF CHEMISTRY | 2013年 / 2013卷
关键词：
POLYMERASE INHIBITORS DISCOVERY; ACID;
D O I：
10.1155/2013/148412
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 5-(2-methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine derivatives (3-5) were synthesized. These previously unknown compounds were characterized by spectral studies and elemental analysis. These compounds were evaluated for their antimicrobial and antioxidant activities. Among all the compounds tested 5d exhibited promising antibacterial, antifungal, radical scavenging, and ferric ions (Fe3+) reducing antioxidant power (FRAP) activities, whereas the compounds 3b, 4c, and 5e exhibited good FRAP and metal chelating activities. In general compounds containing chloro and methyl substituent exhibited better antimicrobial and antioxidant activities.
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页数：9
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