The Synthesis of (1,3,4-Oxadiazol-2-yl)Acrylic Acid Derivatives with Antibacterial and Protistocidal Activities

被引：0
|
作者：
L. D. Popov
A. A. Zubenko
L. N. Fetisov
Yu. D. Drobin
A. I. Klimenko
A. N. Bodryakov
S. A. Borodkin
I. E. Melkozerova
机构：
[1] Southern Federal University,Department of Chemistry
[2] North-Caucasian Zonal Scientific Research Veterinary Institute,undefined
[3] Don State Agrarian University,undefined
[4] Rostov-on-Don Basic Medical College,undefined
来源：
Russian Journal of Bioorganic Chemistry | 2018年 / 44卷
关键词：
acrylic acid; antibacterial activity; 1,3,4-oxadiazol; protistocidal activity;
D O I：
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中图分类号：
学科分类号：
摘要：
A series of new 1,3,4-oxadiazol-2-yl-acrylic acids was synthesized by cyclization of 4-(2-R-hydrazino)- 4-oxo-2-butenic acids, and their antibacterial and protistocidal activities were studied. The p-substituted benzyl derivatives in the Z-form were shown to exhibit a high protistocidal activity, which exceeded that of the reference drug Baycox (toltrazuril) by several times, whereas the 3-hydroxy-2-naphthyl derivative, in addition to a very high protistocidal activity, also exhibited a moderate antibacterial activity.
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页码：238 / 243
页数：5
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