⁢In Vivo⁢ Bioluminescence Imaging of Cobalt Accumulation in a Mouse Model

被引：26

作者：

Ke, Bowen ^{[2
]}

Ma, Lin ^{[1
]}

Kang, Ting ^{[2
]}

He, Wei ^{[2
]}

Gou, Xueyan ^{[2
]}

Gong, Deying ^{[2
]}

Du, Lupei ^{[1
]}

Li, Minyong ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Key Lab Chem Biol MOE, Sch Pharm, Jinan 250012, Shandong, Peoples R China

[2] Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Dept Anaesthesiol & Crit Care Med,West China Brai, Chengdu 610041, Sichuan, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2018年 / 90卷 / 08期

基金：

中国国家自然科学基金;

关键词：

INTRAMOLECULAR PROTON-TRANSFER; IN-VIVO; MURINE MODEL; METAL-IONS; PROBE; COPPER; CO2+; VITAMIN-B-12; SPECTROMETRY; RECOGNITION;

D O I：

10.1021/acs.analchem.8b00391

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

As a trace element nutrient, cobalt is critical for both prokaryotes and eukaryotes. In the current study, a turn-on Cobalt Bioluminescent Probe 1 (CBP-1) for the detection of cobalt has been successfully developed based on oxidative C-O bond cleavage. This probe exhibited high selectivity and sensitivity toward cobalt over other analytes. By using CBP-1, the successful in vivo imaging of cobalt accumulation was carried out in a mouse model. Such an ability to determine cobalt in living animals provides a powerful technology for studying the system distribution, toxic potency, and biological effect of Co2+.

引用

页码：4946 / 4950

页数：5

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