Optimized energy thresholds in a spectral computed tomography scan for contrast agent imaging

被引:2
|
作者
Huang, Kai-Xin [1 ,2 ]
Deng, Zhi [1 ,2 ]
Xu, Xiao-Fei [1 ,2 ]
Xing, Yu-Xiang [1 ,2 ]
机构
[1] Tsinghua Univ, Dept Engn Phys, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Key Lab Particle & Radiat Imaging, Minist Educ, Beijing 100084, Peoples R China
基金
中国国家自然科学基金;
关键词
Spectral CT; Contrast agent imaging; Cramer-Rao lower bound; Thresholds optimization; K-edge; RAY; CT;
D O I
10.1007/s41365-019-0563-9
中图分类号
TL [原子能技术]; O571 [原子核物理学];
学科分类号
0827 ; 082701 ;
摘要
Spectral computed tomography (CT) based on photon counting detectors (PCDs) is a well-researched topic in the field of X-ray imaging. When PCD is applied in a spectral CT system, the PCD energy thresholds must be carefully selected, especially for K-edge imaging, which is an important spectral CT application. This paper presents a threshold selection method that yields better-quality images in K-edge imaging. The main idea is to optimize the energy thresholds ray-by-ray according to the targeted component coefficients, followed by obtaining an overall optimal energy threshold by frequency voting. A low-dose pre-scan is used in practical implementations to estimate the line integrals of the component coefficients for the basis functions. The variance of the decomposed component coefficients is then minimized using the Cramer-Rao lower bound method with respect to the energy thresholds. The optimal energy thresholds are then used to take a full scan and gain better image reconstruction with less noise than would be given by a full scan using the non-optimal energy thresholds. Simulations and practical experiments on imaging iodine and gadolinium solutions, which are commonly used as contrast agents in medical applications, were used to validate the method. The noise was significantly reduced with the same dose relative to the non-optimal energy thresholds in both simulations and in practical experiments.
引用
收藏
页数:13
相关论文
共 50 条
  • [21] Contrast Enhancement Using Curd and Contrast Agent Mixtures for Ex Vivo Vessel Imaging in Computed Tomography
    Obert, M.
    Kohl, L. M.
    Graf, N.
    Krombach, G. A.
    Verhoff, M. A.
    ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2014, 186 (10): : 959 - 961
  • [22] Application of Effective Atomic Number for Contrast Agent Imaging using Dual-energy Computed Tomography: A Simulation Study
    Son, Kihong
    Lee, Seunghyung
    Lee, Hyobin
    Lee, Yejin
    Son, Dongwook
    Myeong, Seunghyeon
    Chang, Minjoo
    Kim, Daehong
    Chung, Myung-Ae
    JOURNAL OF MAGNETICS, 2023, 28 (04) : 443 - 448
  • [23] Contrast agent volume for coronary computed tomography angiography imaging in current clinical practice
    Stocker, Thomas J.
    Bull, Russell
    Buls, Nico
    Leipsic, Jonathon
    Chow, Benjamin
    Maurovich-Horvat, Pal
    Bittencourt, Marcio S.
    Bax, Jeroen J.
    Andreini, Daniele
    Chen, Marcus Y.
    Rubinshtein, Ronen
    Hadamitzky, Martin
    Massberg, Steffen
    Hausleiter, Joerg
    JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 2022, 16 (02) : 191 - 193
  • [24] Functionalizable composite nanoparticles as a dual magnetic resonance imaging/computed tomography contrast agent for medical imaging
    Illert, Patrick
    Waengler, Bjoern
    Waengler, Carmen
    Zoellner, Frank
    Uhrig, Tanja
    Litau, Shanna
    Pretze, Marc
    Roeder, Thorsten
    JOURNAL OF APPLIED POLYMER SCIENCE, 2019, 136 (19)
  • [25] Tailored contrast agent for nuclear spin tomography optimized
    不详
    MRS BULLETIN, 2004, 29 (02) : 79 - 79
  • [27] Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
    James A. Winkelmann
    Aya Eid
    Graham Spicer
    Luay M. Almassalha
    The-Quyen Nguyen
    Vadim Backman
    Light: Science & Applications, 8
  • [28] Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
    Winkelmann, James A.
    Eid, Aya
    Spicer, Graham
    Almassalha, Luay M.
    The-Quyen Nguyen
    Backman, Vadim
    LIGHT-SCIENCE & APPLICATIONS, 2019, 8 (1)
  • [29] Study of Low kV, Low Contrast Agent Dosage, and Low Contrast Agent Flow Rate Scan in Computed Tomography Angiography of Children's Liver
    Wu, Lan
    Tang, Shilong
    Chen, Wushuang
    Chen, Xin
    Zhang, Li
    He, Ling
    IRANIAN JOURNAL OF RADIOLOGY, 2023, 20 (04)
  • [30] Contrast Media in PET/Computed Tomography Imaging
    Dhull, Varun Singh
    Rana, Neelima
    Nazar, Aftab Hasan
    PET CLINICS, 2016, 11 (01) : 85 - +