Novel imidazolopyrimidines as dual PI3-kinase/mTor inhibitors

被引:0
|
作者
Dehnhardt, Christoph [1 ]
Venkatesan, Aranapakam [1 ]
Chen, Zecheng [1 ]
Delos Santos, Efren [1 ]
Santos, Oswaldo [1 ]
Bursavich, Matthew [1 ]
Brooijmans, Natasja [1 ]
Mallon, Robert [1 ]
Hollander, Irwin [1 ]
Feldberg, Larry [1 ]
Lucas, Judy [1 ]
Yu, Ker [1 ]
Ayral-Kaloustian, Semiramis [1 ]
Gibbons, Jay [1 ]
Abraham, Robert [1 ]
Mansour, Tarek [1 ]
机构
[1] Wyeth Res, Pearl River, NY USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2017
引用
收藏
页数:1
相关论文
共 50 条
  • [31] This is your PI3-kinase on drugs
    不详
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (06): : 481 - 481
  • [32] Use of genotoxicity endpoints to determine the genotoxic potential of PI3-kinase inhibitors
    McComb, Catriona M.
    Lynch, Anthony M.
    Austin, Caroline A.
    MUTAGENESIS, 2010, 25 (06) : 649 - 649
  • [33] Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase
    Staben, Steven T.
    Blaquiere, Nicole
    Tsui, Vickie
    Kolesnikov, Aleksandr
    Do, Steven
    Bradley, Erin K.
    Dotson, Jenna
    Goldsmith, Richard
    Heffron, Timothy P.
    Lesnick, John
    Lewis, Cristina
    Murray, Jeremy
    Nonomiya, Jim
    Olivero, Alan G.
    Pang, Jodie
    Rouge, Lionel
    Salphati, Laurent
    Wei, BinQing
    Wiesmann, Christian
    Wu, Ping
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (03) : 897 - 901
  • [34] Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts
    Cao, P.
    Maira, S-M
    Garcia-Echeverria, C.
    Hedley, D. W.
    BRITISH JOURNAL OF CANCER, 2009, 100 (08) : 1267 - 1276
  • [35] Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts
    P Cao
    S-M Maira
    C García-Echeverría
    D W Hedley
    British Journal of Cancer, 2009, 100 : 1267 - 1276
  • [36] Characterization of novel series of selective PI3Kalpha and PI3Kalpha/mTOR-dual inhibitors
    Foster, P.
    Rice, K.
    Bussenius, J.
    Jaeger, C.
    Nguyen, L.
    Virone-Oddos, A.
    Markby, D.
    EJC SUPPLEMENTS, 2010, 8 (07): : 53 - 53
  • [37] A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors
    Yang, Shujie
    Xiao, Xue
    Meng, Xiangbing
    Leslie, Kimberly K.
    PLOS ONE, 2011, 6 (10):
  • [38] Design and synthesis of dual PI3K/mTor inhibitors
    Olivero, Alan
    Heffron, Timothy
    Berry, Leanne
    Berry, Megan
    Castanedo, Georgette
    Chang, Christine
    Dotson, Jennafer
    Friedman, Lori
    Goldsmith, Richard
    Lesnick, John
    Lewis, Cristina
    Mathieu, Simon
    Nonomiya, Jim
    Pang, Jodie
    Peterson, David
    Prior, Wei Wei
    Salphati, Laurent
    Sampath, Deepak
    Sutherlin, Daniel
    Tsui, Vickie
    Ultsch, Mark
    Wang, Shumei
    Wiesmann, Christian
    Wong, Susan
    Zhu, Bing-Yan
    Chuckowree, Irina
    Folkes, Adrian
    Shuttleworth, Steve
    CANCER RESEARCH, 2009, 69
  • [39] In vitro and in vivo efficacy of the dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in renal cell carcinoma (RCC)
    Cho, Daniel
    Cohen, Matthew
    Panka, David
    Bhatt, Rupal
    Signoretti, Sabina
    Atkins, Michael
    Mier, James
    CANCER RESEARCH, 2009, 69
  • [40] The expanding role of PI3-kinase in bone
    Golden, LH
    Insogna, KL
    BONE, 2004, 34 (01) : 3 - 12