Nitric oxide-dependent suppression of flavin-containing monooxygenase expression in rat liver

被引：0
|
作者：
Park, CS [1 ]
Baek, HM [1 ]
Chung, WG [1 ]
Lee, KH [1 ]
Ryu, SD [1 ]
Cha, YN [1 ]
机构：
[1] Inha Univ, Coll Med, Dept Pharmacol & Toxicol, Inchon 402751, South Korea
来源：
BIOLOGY OF NITRIC OXIDE, PT 7 | 2000年 / 16卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liver microsomal FMO activities of LPS-treated rats were decreased significantly. Hepatic content of FMO1 mRNA and tile liver microsomal content of FMO I (the major form in rat liver) in LPS-treated rats were significantly decreased also, However. the expression of inducible NO synthase (iNOS) and plasma nitrate/nitrite (NOx) concentration were increased. In rats cotreated with NOS inhibitors such as aminoguanidine and nitro L-arginine. the ativities and content of FMO1 in liver microsomes were restored. These results suggest that NO is an important mediator involved in the suppression of FMO1 activity in vivo.
引用
收藏
页码：123 / 123
页数：1
相关论文
共 50 条
  • [41] TISSUE-DEPENDENT AND SPECIES-DEPENDENT EXPRESSION OF MULTIPLE FORMS OF MAMMALIAN MICROSOMAL FLAVIN-CONTAINING MONOOXYGENASE
    TYNES, RE
    PHILPOT, RM
    MOLECULAR PHARMACOLOGY, 1987, 31 (06) : 569 - 574
  • [42] Hepatic Flavin-Containing Monooxygenase 3 Enzyme Suppressed by Type 1 Allergy-Produced Nitric Oxide
    Tanino, Tadatoshi
    Bando, Toru
    Komada, Akira
    Nojiri, Yukie
    Okada, Yuna
    Ueda, Yukari
    Sakurai, Eiichi
    DRUG METABOLISM AND DISPOSITION, 2017, 45 (11) : 1189 - 1196
  • [43] METABOLISM OF BENZIMIDAZOLINE-2-THIONES BY RAT HEPATIC MICROSOMES AND HOG LIVER FLAVIN-CONTAINING MONOOXYGENASE
    DECKER, CJ
    DOERGE, DR
    CASHMAN, JR
    CHEMICAL RESEARCH IN TOXICOLOGY, 1992, 5 (05) : 726 - 733
  • [44] COVALENT STRUCTURE OF LIVER MICROSOMAL FLAVIN-CONTAINING MONOOXYGENASE FORM-1
    OZOLS, J
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (18) : 10289 - 10299
  • [45] Human Flavin-Containing Monooxygenase 3 on Graphene Oxide for Drug Metabolism Screening
    Castrignano, Silvia
    Gilardi, Gianfranco
    Sadeghi, Sheila J.
    ANALYTICAL CHEMISTRY, 2015, 87 (05) : 2974 - 2980
  • [46] PURIFICATION OF THE FLAVIN-CONTAINING MONOOXYGENASE FROM MOUSE AND PIG-LIVER MICROSOMES
    SABOURIN, PJ
    SMYSER, BP
    HODGSON, E
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1984, 16 (07): : 713 - &
  • [47] Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes
    Yanni, Souzan B.
    Annaert, Pieter P.
    Augustijns, Patrick
    Bridges, Arlene
    Gao, Yan
    Benjamin, Daniel K., Jr.
    Thakker, Dhiren R.
    DRUG METABOLISM AND DISPOSITION, 2008, 36 (06) : 1119 - 1125
  • [48] CATALYTIC ACTIVITY AND IMMUNOHISTOCHEMICAL LOCALIZATION OF FLAVIN-CONTAINING MONOOXYGENASE IN RAT-KIDNEY
    BHAMRE, S
    SHANKAR, SK
    BHAGWAT, SV
    RAVINDRANATH, V
    LIFE SCIENCES, 1993, 52 (20) : 1601 - 1607
  • [49] EXPRESSION OF FLAVIN-CONTAINING MONOOXYGENASE ACTIVITY IN ADULT-RAT HEPATOCYTES UNDER VARIOUS CULTURE CONDITIONS
    COECKE, S
    SEGAERT, A
    VERCRUYSSE, A
    ROGIERS, V
    TOXICOLOGY IN VITRO, 1993, 7 (04) : 487 - 491
  • [50] Over production of nitric oxide and peroxynitrite in patients with liver cirrhosis and cancer suppresses flavin-containing monooxygenase (FMO) activity and causes trimethylaminuria (TMAU)
    Yi, HG
    Park, CS
    Kang, JS
    Kang, JH
    Chung, WG
    Pie, JE
    Ryu, SD
    Choi, W
    Cha, YN
    FASEB JOURNAL, 2001, 15 (04): : A576 - A576
12345