Nitric oxide-dependent suppression of flavin-containing monooxygenase expression in rat liver

被引：0
|
作者：
Park, CS [1 ]
Baek, HM [1 ]
Chung, WG [1 ]
Lee, KH [1 ]
Ryu, SD [1 ]
Cha, YN [1 ]
机构：
[1] Inha Univ, Coll Med, Dept Pharmacol & Toxicol, Inchon 402751, South Korea
来源：
BIOLOGY OF NITRIC OXIDE, PT 7 | 2000年 / 16卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liver microsomal FMO activities of LPS-treated rats were decreased significantly. Hepatic content of FMO1 mRNA and tile liver microsomal content of FMO I (the major form in rat liver) in LPS-treated rats were significantly decreased also, However. the expression of inducible NO synthase (iNOS) and plasma nitrate/nitrite (NOx) concentration were increased. In rats cotreated with NOS inhibitors such as aminoguanidine and nitro L-arginine. the ativities and content of FMO1 in liver microsomes were restored. These results suggest that NO is an important mediator involved in the suppression of FMO1 activity in vivo.
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页码：123 / 123
页数：1
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