Treatment of Radiation-Induced Cognitive Decline in Adult Brain Tumor Patients

被引：36
|
作者：
Cramer, Christina K. [1 ]
Cummings, Tiffany L. [2 ]
Andrews, Rachel N. [3 ]
Strowd, Roy [4 ]
Rapp, Stephen R. [5 ,6 ]
Shaw, Edward G. [7 ]
Chan, Michael D. [1 ]
Lesser, Glenn J. [8 ]
机构：
[1] Wake Forest Baptist Med Ctr, Dept Radiat Oncol, Med Ctr Blvd, Winston Salem, NC 27157 USA
[2] Wake Forest Baptist Med Ctr, Dept Neurol, Winston Salem, NC 27157 USA
[3] Wake Forest Baptist Med Ctr, Dept Radiat Oncol, Sect Radiat Biol, Med Ctr Blvd, Winston Salem, NC 27157 USA
[4] Wake Forest Baptist Med Ctr, Dept Hematol Oncol, Winston Salem, NC 27157 USA
[5] Wake Forest Sch Med, Dept Psychiat & Behav Med, Med Ctr Blvd, Winston Salem, NC USA
[6] Wake Forest Sch Med, Div Publ Hlth Sci Social Sci & Hlth Policy, Med Ctr Blvd, Winston Salem, NC USA
[7] Wake Forest Baptist Hlth, Memory Counseling Program, Sect Gerontol & Geriatr Med, Sticht Ctr Hlth Aging & Alzheimers Prevent, Med Ctr Blvd, Winston Salem, NC 27157 USA
[8] Wake Forest Baptist Comprehens Canc Ctr, Oncol, Med Neurooncol & Neurooncol Res Program, Med Ctr Blvd, Winston Salem, NC 27157 USA
来源：
CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2019年 / 20卷 / 05期
关键词：
Cognition; Brain; Radiation; Neuropsychology; Memory; Attention; NF-KAPPA-B; ALZHEIMERS ASSOCIATION WORKGROUPS; OLIGODENDROCYTE PROGENITOR CELLS; WHITE-MATTER HYPERINTENSITIES; DOUBLE-BLIND; PHASE-III; HIPPOCAMPAL NEUROGENESIS; X-IRRADIATION; NEUROCOGNITIVE FUNCTION; DIAGNOSTIC GUIDELINES;
D O I：
10.1007/s11864-019-0641-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Patients with either primary or metastatic brain tumors quite often have cognitive impairment. Maintaining cognitive function is important to brain tumor patients and a decline in cognitive function is generally accompanied by a decline in functional independence and performance status. Cognitive decline can be a result of tumor progression, depression/anxiety, fatigue/sleep dysfunction, or the treatments they have received. It is our opinion that providers treating brain tumor patients should obtain pre-treatment and serial cognitive testing in their patients and offer mitigating and therapeutic interventions when appropriate. They should also support cognition-focused clinical trials. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
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页数：16
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