Anatomical aspects, chemical analysis and cytotoxic effect of the essential oil from leaves of Casearia arborea (Salicaceae)

被引：0

作者：

Pereira, Flaviane Gomes ^{[1
]}

Marquete, Ronaldo ^{[2
]}

Leite, Kosme Oliveira ^{[3
]}

Cabral, Otavio Versiane ^{[3
]}

May, Barrie ^{[4
]}

Mansur, Elisabeth ^{[5
]}

Moreira, Davyson de Lima ^{[6
]}

机构：

[1] Univ Fed Rio de Janeiro, Programa Posgrad Biotecnol Vegetal & Bioproc, BR-21941 Rio De Janeiro, Brazil

[2] Coordenadoria Recursos Nat CREN, Diretoria Geociencias, IBGE, Rio De Janeiro, Brazil

[3] Inst Fed Educ Ciencia & Tecnol Rio de Janeiro IFR, Rio De Janeiro, Brazil

[4] TreeMod Co, Glen Waverley, Vic 3150, Australia

[5] Univ Estado Rio de Janeiro UERJ, Dept Biol, Rio De Janeiro, Brazil

[6] Fundacao Oswado Cruz Fiocruz, Dept Nat Prod, Inst Tecnol Farmacos, Rio De Janeiro, Brazil

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2017年 / 16卷 / 02期

关键词：

A549; byciclogermacrene; Casearia arborea; salicaceae; secretory cavities; sesquiterpene; SYLVESTRIS; ANTIOXIDANT; DITERPENES;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The genus Casearia (Salicaceae) is found in sub-tropical and tropical regions of the world and comprises about 200 species. In Brazil, there are about 48 species and 12 are registered in the State of Rio de Janeiro; including Casearia arborea (Rich.) Urb. Essential oil was obtained from the fresh leaves by hydrodistillation and analyzed by GC-MS and GC-FID. The cytotoxic effect was determined by WST-1 assay. Chemical analysis of the essential oil revealed a very diversified (n = 37 compounds) volatile fraction composed mainly of non-oxygenated sesquiterpenes (90.2%). These sesquiterpenes included byciclogermacrene (18.7%), germacrene D (12.1%) and alpha-humulene (11.5%). In addition, the essential oil demonstrated cytotoxic effects against A549 tumor cells in the concentration of 4 mu g/mL (EC50) (p < 0.05).

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页码：99 / 109

页数：11

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