N-H Spin-Spin Couplings: Probing Hydrogen Bonds in Proteins

被引：14
|
作者：
Xiang, Sheng-Qi [1 ]
Narayanan, Raghavendran L. [1 ]
Becker, Stefan [1 ]
Zweckstetter, Markus [1 ,2 ]
机构：
[1] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany
[2] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, D-37077 Gottingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 12期
关键词：
amides; coupling constants; hydrogen bonds; NMR spectroscopy; proteins; SCALAR COUPLINGS; DIPOLAR COUPLINGS; N-15-H-1; SCALAR; CHEMICAL-SHIFTS; CONSTANTS; UBIQUITIN; BINDING; TAU;
D O I：
10.1002/anie.201209641
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sensitive information: Hydrogen bonds stabilize protein structures and are critical for many chemical and biological phenomena. NMR studies found that the one-bond 1H-15N scalar coupling constant is increased by up to 1.6 Hz when a hydrogen bond is formed. These coupling constants therefore provide a sensitive tool for studying protein structure. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3525 / 3528
页数：4
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