Synthesis and anti-inflammatory activity of 1-acetyl/propanoyl-5-aryl-3-(4-morpholinophenyl)-4,5-dihydro-1H-pyrazole derivatives

被引：8
|
作者：
Khalil, Omneya M. [1 ]
机构：
[1] Cairo Univ, Dept Organ Chem, Fac Pharm, Cairo 11562, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期
关键词：
Synthesis; Pyrazolines; Anti-inflammatory activity; PYRAZOLINE DERIVATIVES; ANTIMICROBIAL EVALUATION; SCHIFF-BASES; AGENTS;
D O I：
10.1007/s00044-011-9862-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel pyrazoline derivatives containing 4-morpholinophenyl moiety were synthesized to investigate their potential anti-inflammatory activity. The chemical structures of the compounds were elucidated by spectral data and element analyses. The test compounds in the series exhibited different levels of anti-inflammatory activities when compared with reference drug indomethacin.
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页码：3240 / 3245
页数：6
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