Synthesis and anti-inflammatory activity of 1-acetyl/propanoyl-5-aryl-3-(4-morpholinophenyl)-4,5-dihydro-1H-pyrazole derivatives

被引：8
|
作者：
Khalil, Omneya M. [1 ]
机构：
[1] Cairo Univ, Dept Organ Chem, Fac Pharm, Cairo 11562, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期
关键词：
Synthesis; Pyrazolines; Anti-inflammatory activity; PYRAZOLINE DERIVATIVES; ANTIMICROBIAL EVALUATION; SCHIFF-BASES; AGENTS;
D O I：
10.1007/s00044-011-9862-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel pyrazoline derivatives containing 4-morpholinophenyl moiety were synthesized to investigate their potential anti-inflammatory activity. The chemical structures of the compounds were elucidated by spectral data and element analyses. The test compounds in the series exhibited different levels of anti-inflammatory activities when compared with reference drug indomethacin.
引用
下载
收藏
页码：3240 / 3245
页数：6
相关论文
共 50 条
  • [31] Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways
    Can, Ozgur Devrim
    Alyu, Feyza
    Turan, Nazli
    Ozdemir, Ahmet
    LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 13 (05) : 411 - 417
  • [32] 3,5-Bis(4-fluorophenyl)-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole
    Samshuddin, Seranthimata
    Narayana, Badiadka
    Yathirajan, Hemmige S.
    Gerber, Thomas
    Hosten, Eric
    Betz, Richard
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3216 - +
  • [33] Synthesis, Pharmacological Evaluation and Docking Study of Novel 3-Phenyl-5-Aryl-4, 5-Dihydro-1h-Pyrazole-1-Carbaldehyde as Anti-Inflammatory Agents
    Nikalje, Anna Pratima G.
    Gaikwad, Gaurav
    Nawale, Rajesh
    Sangshetti, Jaiprakash
    Khan, Firoz A.
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2015, 6 (02): : 423 - 431
  • [34] 3,5-Bis(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    Safwan, A. P.
    Tiekink, Edward R. T.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1279 - U299
  • [35] 3,5-Bis(4-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Jasinski, Jerry P.
    Guild, Curtis J.
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1948 - U607
  • [36] 3,5-Bis(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Butcher, Ray J.
    Akkurt, Mehmet
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1019 - U1765
  • [37] 5-(2-Furyl)-3-methyl-1-(3-nitrophenyl)-4,5-dihydro-1H-pyrazole
    Chen, Jun-qiang
    Li, He-ping
    Huang, Chang-shan
    Wu, Jin-ying
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2147 - U1969
  • [38] CRYSTAL-STRUCTURE OF 4-HYDROXY-4(3-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRAZO-4-YL)-3-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRAZOLE
    RAMM, M
    BISCHOFF, C
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 1994, 209 (05): : 427 - 429
  • [39] Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives
    dos Santos, Mauricio S.
    Oliveira, Mariana L. V.
    Bernardino, Alice M. R.
    de Leo, Rosa M.
    Amaral, Veronica F.
    de Carvalho, Flavia T.
    Leon, Leonor L.
    Canto-Cavalheiro, Marilene M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (24) : 7451 - 7454
  • [40] 3,5-Bis(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Baktir, Zeliha
    Akkurt, Mehmet
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O328 - U295
12345