Enantioselective C2-H Alkylation of Pyridines with 1,3-Dienes via Ni-Al Bimetallic Catalysis

被引：46
|
作者：
Li, Jiang-Fei [1 ,2 ]
Pan, Deng [3 ,4 ]
Wang, Hao-Rui [1 ,2 ]
Zhang, Tao [1 ,2 ]
Li, Yi [1 ,2 ]
Huang, Genping [3 ,4 ]
Ye, Mengchun [1 ,2 ,5 ]
机构：
[1] Nankai Univ, Coll Chem, Frontiers Sci Ctr New Organ Matter, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Inst Elementoorgan Chem, Coll Chem, Frontiers Sci Ctr New Organ Matter, Tianjin 300071, Peoples R China
[3] Tianjin Univ, Sch Sci, Dept Chem, Tianjin 300072, Peoples R China
[4] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China
[5] Haihe Lab Sustainable Chem Transformat, Tianjin 300192, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2022年 / 144卷 / 41期
基金：
中国国家自然科学基金;
关键词：
C-H BOND; SELECTIVE ALKENYLATION; KINETIC RESOLUTION; ACTIVATION; METAL; FUNCTIONALIZATION; HYDROHETEROARYLATION; SUBSTITUTIONS; HETEROCYCLES; COMBINATION;
D O I：
10.1021/jacs.2c09306
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A chiral phosphine oxide-ligated Ni-Al bimetallic catalyst was used to realize an enantioselective C2-H alkylation of pyridines without the need of a C2-block. A wide range of pyridines, including unsubstituted pyridine, C3, C4, and C2-substituted pyridines, and even complex pyridine-containing bioactive molecules are well compatible with the reaction, providing up to 81% yield and up to 97% ee.
引用
收藏
页码：18810 / 18816
页数：7
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