Enantioselective [3+2] annulation via C-H activation between cyclic N-acyl ketimines and 1,3-dienes catalyzed by iridium/chiral diene complexes

被引：102

作者：

Nishimura, Takahiro ^{[1
]}

Nagamoto, Midori ^{[1
]}

Ebe, Yusuke ^{[1
]}

Hayashi, Tamio ^{[2
,3
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo, Kyoto 6068502, Japan

[2] ASTAR, Inst Mat Res & Engn, Singapore 117602, Singapore

[3] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

CHEMICAL SCIENCE | 2013年 / 4卷 / 12期

关键词：

CARBON-HYDROGEN BONDS; ASYMMETRIC CATALYSIS; CONJUGATE ADDITION; AROMATIC KETONES; HIGHLY EFFICIENT; CHIRAL LIGANDS; ARYL KETONES; ARYLATION; ALKYNES; FUNCTIONALIZATION;

D O I：

10.1039/c3sc52379a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective [3 + 2] annulation between 1,3-dienes and N-acyl ketimines in situ generated from 3-aryl-3-hydroxyisoindolin-1-ones proceeded via C-H activation to give spiroaminoindane derivatives in high yields with high regio-and enantioselectivity, which is realized by use of an Ir/chiral diene catalyst.

引用

页码：4499 / 4504

页数：6

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