Synthesis of four new carboxylic derivatives based on the [1.1.1.1]metacyclophane backbone blocked in 1,3-Alternate conformation

Four new tetrasubstituted [1.1.1.1]metacyclophanes (4-7), that are inherently adopting a 1,3-Alternate conformation, bearing four or eight peripheral carboxylic binding sites, and appended with spacers group (alkyl or phenyl) differing by the flexibility, have been synthesised in high yields. The structures of the obtained compounds have been investigated in solution as well as in the solid state, for three of them, by using single-crystal X-ray analysis. (C) 2018 Elsevier Ltd. All rights reserved.