A partial synthesis of 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from betulinic acid

被引：6
|
作者：
Sun, Fei [1 ]
Zhu, Peiqing [1 ]
Yao, Hequan [1 ]
Wu, Xiaoming [1 ]
Xu, Jinyi [1 ]
机构：
[1] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2012年 / 05期
关键词：
betulinic acid; 23-hydroxybetulonic acid; 23-hydroxybetulinic acid; cyclopalladation; Baldwin's method; ANTITUMOR-ACTIVITY; METHYL-GROUPS; CYCLOPALLADATION; DERIVATIVES;
D O I：
10.3184/174751912X13332875186150
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A partial syntheses of the biologically active 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from the naturally abundant betulinic acid has been developed in which the key step was the Baldwin's cyclopalladation of the 23-methyl group from a 3-one oxime of betulinic acid, an important drug in Chinese medicine.
引用
收藏
页码：254 / 257
页数：4
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