Synthesis and α-Glucosidase Inhibitory Activity of Ursolic Acid, Lupeol, and Betulinic Acid Derivatives

被引：0

作者：

Ngoc-Hong Nguyen

Duc Dung Pham

Thi-Thanh-Van Le

Thi-Anh-Tuyet Nguyen

Dinh-Long Huynh

Thuc-Huy Duong

Jirapast Sichaem

机构：

[1] Ho Chi Minh City University of Technology (HUTECH),CirTech Institute

[2] Ho Chi Minh City University of Education,Department of Chemistry

[3] Thammasat University Lampang Campus,Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology

来源：

Chemistry of Natural Compounds | 2021年 / 57卷

关键词：

pentacyclic triterpenoids; synthesis; oxone oxidation; α-glucosidase inhibition;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Seven synthetic derivatives of ursolic acid, lupeol, and betulinic acid (1a–1b, 2a–2b, and 3a–3c) were synthesized to study their α-glucosidase inhibitory activity. Three of them (2b, 3b, and 3c) are new compounds. Among the synthetic derivatives, betulinic acid analogues 3b and 3c exhibited the best activity against α-glucosidase and is superior to the positive agent, with IC50 values of 35.0 ± 3.37 and 34.0 ± 1.24 μM, respectively.

引用

页码：1038 / 1041

页数：3

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