Co-expression of p16/ki-67 in Associated with Human Papilloma Virus Type 16

被引：0

作者：

Balint, Oana ^{[1
]}

Secosan, Cristina ^{[1
]}

Grigoras, Dorin ^{[1
,2
]}

Ilina, Razvan ^{[3
]}

Levai, Codrina Mihaela ^{[4
]}

Sas, Ioan ^{[1
,2
]}

机构：

[1] Cty Hosp Timisoara, Dept Obstet & Gynecol, 156 Liviu Rebreanu, Timisoara 300723, Romania

[2] Univ Med & Farm Timisoara, Dept Obstet & Gynecol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[3] Victor Babes Univ Med & Pharm, Dept Surg, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[4] Victor Babes Univ Med & Pharm, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

来源：

MATERIALE PLASTICE | 2017年 / 54卷 / 03期

关键词：

HPV immunocytochemistry; cervical cancer; p16; DUAL-STAINED CYTOLOGY; CERVICAL INTRAEPITHELIAL NEOPLASIA; AMERICAN-CANCER-SOCIETY; NATURAL-HISTORY; INFECTION; PERSISTENCE; WOMEN; RISK; PROGRESSION; CLEARANCE;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The current trend in screening against cervical cancer is to improve the sensitivity of screening method and p16/Ki-67 dual-stained cytology, represents a promising approach. We performed a study to investigate the correlation between the p16/Ki-67 co-expression and HPV type on a group of patients with ASCUS and LSIL on Pap smear. On all patients, dual stain test and HPV genotyping were performed. In the group of patients with positive dual stain p16/Ki-67 test, the number of patients with HPV type 16 was significantly higher than the number of patients with any other type of HPV. Also, all patients with CIN3 or above (cervical cancer) were positive for p16/Ki-67. Our study shows the potential use of those two tests to identify patients with high risk for severe dysplasia.

引用

页码：549 / 552

页数：4

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