Two New Triterpenoids from the Roots of Codonopsis pilosula

被引：18

作者：

Zheng, Tao ^{[1
,2
]}

Cheng, Li-Zhi ^{[3
]}

Yan, Yong-Ming ^{[3
]}

Liu, Bao-Hua ^{[3
]}

Qin, Fu-Ying ^{[1
,3
]}

Xu, Fu-Rong ^{[2
]}

Cheng, Yong-Xian ^{[1
,2
,3
,4
]}

机构：

[1] Yunnan Univ Tradit Chinese Med, Coll Pharm, Kunming 650504, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[3] Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China

[4] Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 02期

关键词：

Codonopsis pilosula; pseudolarolides; triterpenoids; SIRT1; PSEUDOLARIX-KAEMPFERI; PYRROLIDINE ALKALOIDS; STEREOCHEMISTRY; DILACTONE; LACTONES; SIRT1;

D O I：

10.3390/molecules23020383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudolarolides U and V, two new triterpenoids, and four biogenetically related compounds, pseudolarolides E, F, K, and P were isolated from the roots of Codonopsis pilosula (Campanulaceae). Their structures were determined by spectroscopic data. The regulation of Sirtuin 1 (SIRT1) activity by all the isolated compounds was evaluated.

引用

页数：7

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