CuBr/proline-catalyzed cross-coupling of unactivated benzene with aryl halides

被引：7

作者：

Liu, Wei ^{[1
]}

Hou, Fanyi ^{[1
]}

机构：

[1] Henan Univ Technol, Coll Food Sci & Technol, Zhengzhou 450001, Henan, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2015年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Cu catalysis; CH activation; direct CH arylation; unactivated arenes; aryl halides; C-H ARYLATION; BOND FORMATION; ARENES; PALLADIUM; NAPHTHALENE; ACTIVATION; PRODUCTS; ACID;

D O I：

10.1002/aoc.3300

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Direct CH arylation of unactivated benzene with aryl halides was achieved using a readily available copper catalyst. The reaction was carried out at 80 degrees C, using CuBr as catalyst, proline as ligand and t-BuOK as base. This radical cross-coupling reaction between unactivated benzene and aryl iodides proceeds via homolytic aromatic substitution and offers an efficient method for the synthesis of various biaryls in good to excellent yields. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：368 / 371

页数：4

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