Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides

被引：12
|
作者：
Ren, Jing-Ao [1 ]
Na, Jin-He [1 ]
Gui, Chao [1 ]
Miao, Chengping [2 ]
Chu, Xue-Qiang [1 ]
Ma, Mengtao [3 ]
Xu, Hao [1 ]
Zhou, Xiaocong [1 ,2 ]
Shen, Zhi-Liang [1 ]
机构：
[1] Nanjing Tech Univ, Tech Inst Fluorochemistry TIF, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China
[2] Jiaxing Univ, Coll Biol Chem Sci & Engn, 118 Jiahang Rd, Jiaxing 314001, Peoples R China
[3] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 29期
基金：
中国国家自然科学基金;
关键词：
POLYFLUOROALKYL KETONES; HALIDES; ACTIVATION;
D O I：
10.1021/acs.orglett.3c02000
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nickel-catalyzeddirect cross-coupling of unactivated aryl fluorideswith aryl bromides is realized. The one-pot reaction, which avoidsthe use of preformed and sensitive organometallic reagents, proceedseffectively via C-F bond cleavage at room temperature in THFin the presence of the phosphine ligand and magnesium powder (withor without TMSCl) to produce the desired biaryls in modest to goodyields.
引用
收藏
页码：5525 / 5529
页数：5
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