Bladder Cancer Stem Cells: Biological and Therapeutic Perspectives

被引：0

作者：

Jinesh, Goodwin G. ^{[1
]}

Willis, Daniel Levi ^{[1
]}

Kamat, Ashish M. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2014年 / 9卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Blebbishields; cancer stem cells; CD44; c-Met; neutrophils; T-cells; VEGFR2; BACILLUS-CALMETTE-GUERIN; SIDE-POPULATION CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; APOPTOSIS-INDUCING LIGAND; FAS-LIGAND; IN-VITRO; TUMOR-CELLS; SOLUBLE FAS; NEOADJUVANT CHEMOTHERAPY; MOLECULAR HETEROGENEITY;

D O I：

暂无

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Bladder cancer stem cell research is rapidly expanding based on the knowledge of cancer stem cells from various cancer types and normal stem cells as models. In various cancer types, cancer stem cells have been implicated in therapeutic resistance and relapse after initial therapy. Understanding how cancer stem cells differ from bulk cancer cells and how cancer stem cells contribute to relapse and resistance are essential to develop novel therapeutics to target cancer stem cells effectively. Here we review the latest information on bladder cancer stem cells, their biological characteristics, including their response to treatment, recurrence, immune context and technical problems encountered in bladder cancer stem cell research.

引用

页码：89 / 101

页数：13

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