Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas

被引：19

作者：

Kamila, Sukanta ^{[1
]}

Mendoza, Kimberly ^{[1
]}

Biehl, Edward R. ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 37期

关键词：

Microwave irradiation; (6-Phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amine 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones; 6-Phenylimidazo[2,1-b]thiazoles; ONE-POT SYNTHESIS; DERIVATIVES; ANTITUMOR; EFFICIENT;

D O I：

10.1016/j.tetlet.2012.06.116

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (6a-q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones (4a-e) with suitably substituted thioureas using microwave heating. The ethanones (4a-e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (3a-e) with chloroacetylchloride in refluxing 1,4-dioxane whereas the thiazoles (3a-e) were synthesized by the reaction of 2-bromo-1-phenylethanones (2a-e) with thiazol-2-amine in refluxing acetone. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4921 / 4924

页数：4

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