Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas

被引：19
|
作者：
Kamila, Sukanta [1 ]
Mendoza, Kimberly [1 ]
Biehl, Edward R. [1 ]
机构：
[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 37期
关键词：
Microwave irradiation; (6-Phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amine 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones; 6-Phenylimidazo[2,1-b]thiazoles; ONE-POT SYNTHESIS; DERIVATIVES; ANTITUMOR; EFFICIENT;
D O I：
10.1016/j.tetlet.2012.06.116
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (6a-q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones (4a-e) with suitably substituted thioureas using microwave heating. The ethanones (4a-e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (3a-e) with chloroacetylchloride in refluxing 1,4-dioxane whereas the thiazoles (3a-e) were synthesized by the reaction of 2-bromo-1-phenylethanones (2a-e) with thiazol-2-amine in refluxing acetone. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4921 / 4924
页数：4
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