Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction

被引：7
|
作者：
Shen, Sida [1 ]
Pham Van Khang [1 ]
Chen, Yijia [2 ]
Lei, Min [2 ]
Hu, Lihong [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[2] Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
来源：
ARKIVOC | 2013年
基金：
中国国家自然科学基金;
关键词：
2-cyanobenzaldehyde; 3-methyl-1H-pyrazol-5(4H)-one; 1,3-dimethyl-1H-pyrazol-5(4H)-one; isoindolin-1-imine; multi-component reaction; 2-CYANOBENZALDEHYDE;
D O I：
10.3998/ark.5550190.p007.992
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, one-pot method has been developed for the synthesis of 4-(2-substituented-3-iminoisoindolin-1-ylidene)-1-substitueted-3-methyl-1H-pyrazol-5(4H)-one derivatives via cascade three-component condensation of 2-cyanobenzaldehyde, amine, and 3-methyl-1H-pyrazol-5(4H)-one or 1,3-dimethyl-1H-pyrazol-5(4H)-one. The efficient and convenient reaction conditions provide the corresponding products from various substrates under reflux condition in ethanol with excellent yields (85-95%).
引用
收藏
页码：413 / 423
页数：11
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