Synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives via an unusual Delepine reaction

被引：0
|
作者：
Levkov, Igor, V [1 ]
Kysil, Andrii, I [1 ]
Biitseva, Angelina, V [1 ]
Shilin, Sergey, V [1 ]
Saffon-Merceron, Nathalie [2 ]
Yegorova, Tatyana, V [1 ]
Voitenko, Zoia V. [1 ]
机构：
[1] Taras Shevchenko Natl Univ Kyiv, 64-13 Volodymyrska Str, UA-01601 Kiev, Ukraine
[2] Univ Toulouse, UPS, ICT FR 2599, 118 Route Narbonne, F-31062 Toulouse 9, France
来源：
TETRAHEDRON LETTERS | 2021年 / 67卷
关键词：
2-(methoxymethyl)isoindolin-1-imine; 2-methoxymethyl-2H-isoindo1-1-amine; Delepine reaction; o-Bromomethylbenzonitrile;
D O I：
10.1016/j.tetlet.2021.152866
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 2-(methoxymethyl)isoindolin-l-imine derivatives via an unusual Delepine reaction is reported. The substrate substituents' influence on the reaction course was studied, and a possible reaction mechanism proposed. The structure of 2-(methoxymethyl)isoindolin-1-imine was confirmed by X-ray diffraction analysis. (C) 2021 Elsevier Ltd. All rights reserved.
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