A one-pot synthesis of isoindolin-1-imine derivatives

被引：6
|
作者：
Khangvan Pham [1 ]
Zhang, Zhongguo [1 ]
Shen, Sida [1 ]
Ma, Lei [1 ]
Hu, Lihong [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 51期
基金：
中国国家自然科学基金;
关键词：
2-Cyanobenzaldehyde; 4-Hydroxycoumarin; Isoindolin-l-imine; 4-Hydroxyquinolin-2(1H)-one; One-pot reaction; THIAMINE HYDROCHLORIDE; GLYCINE SITE; RECEPTOR; ANTAGONISTS; DICUMAROL; BINDING; AMINO;
D O I：
10.1016/j.tet.2013.10.076
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot procedure was developed for the synthesis of isoindolin-l-imine derivatives by a simple three-component condensation of 2-cyanobenzaldhyde, ammonium acetate, and 4-hyroxycoumarin derivatives or 1,3-dicarbonyl compounds or 4-hydroxyquinolin-2(1H)-one in ethanol under reflux for 20-60 min with excellent yields. The advantages of this procedure are operational simplicity, excellent yields, and short reactive time, without catalyst, easy workup, and green environmental impact. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10933 / 10939
页数：7
相关论文
共 50 条
  • [1] Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction
    Shen, Sida
    Pham Van Khang
    Chen, Yijia
    Lei, Min
    Hu, Lihong
    ARKIVOC, 2013, : 413 - 423
  • [2] Synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives via an unusual Delepine reaction
    Levkov, Igor, V
    Kysil, Andrii, I
    Biitseva, Angelina, V
    Shilin, Sergey, V
    Saffon-Merceron, Nathalie
    Yegorova, Tatyana, V
    Voitenko, Zoia V.
    TETRAHEDRON LETTERS, 2021, 67
  • [3] Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium
    Shen, Sida
    Chen, Yijia
    Lei, Min
    Hu, Lihong
    MONATSHEFTE FUR CHEMIE, 2015, 146 (09): : 1571 - 1580
  • [4] Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium
    Sida Shen
    Yijia Chen
    Min Lei
    Lihong Hu
    Monatshefte für Chemie - Chemical Monthly, 2015, 146 : 1571 - 1580
  • [5] One-pot synthesis of imidazopyridine derivatives
    Parenty, Alexis D. C.
    Cronin, Leroy
    SYNTHESIS-STUTTGART, 2008, (09): : 1479 - 1485
  • [6] One-pot synthesis of coumarin derivatives
    Ye, Fang-Fang
    Gao, Jian-Rong
    Sheng, Wei-Jian
    Jia, Jian-Hong
    DYES AND PIGMENTS, 2008, 77 (03) : 556 - 558
  • [7] One-pot synthesis of cotarnine 1-alkynyl derivatives
    Ukhin, L. Yu.
    Shepelenko, E. N.
    Belousova, L. V.
    Popova, O. S.
    Alekseenko, D. V.
    RUSSIAN CHEMICAL BULLETIN, 2016, 65 (03) : 831 - 833
  • [8] One-pot synthesis of cotarnine 1-alkynyl derivatives
    L. Yu. Ukhin
    E. N. Shepelenko
    L. V. Belousova
    O. S. Popova
    D. V. Alekseenko
    Russian Chemical Bulletin, 2016, 65 : 831 - 833
  • [9] A one-pot synthesis of 1,3-dioxazine-4-one derivatives
    Saidi, K
    Shaterian, H
    Aghaei, D
    HETEROCYCLIC COMMUNICATIONS, 2000, 6 (01) : 93 - 96
  • [10] One-Pot Synthesis of α-Alkyl Styrene Derivatives
    Ojo, Olatunji S.
    Bugarin, Alejandro
    ACS OMEGA, 2021, 6 (31): : 20619 - 20628
12345