A one-pot synthesis of isoindolin-1-imine derivatives

被引：6
|
作者：
Khangvan Pham [1 ]
Zhang, Zhongguo [1 ]
Shen, Sida [1 ]
Ma, Lei [1 ]
Hu, Lihong [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 51期
基金：
中国国家自然科学基金;
关键词：
2-Cyanobenzaldehyde; 4-Hydroxycoumarin; Isoindolin-l-imine; 4-Hydroxyquinolin-2(1H)-one; One-pot reaction; THIAMINE HYDROCHLORIDE; GLYCINE SITE; RECEPTOR; ANTAGONISTS; DICUMAROL; BINDING; AMINO;
D O I：
10.1016/j.tet.2013.10.076
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot procedure was developed for the synthesis of isoindolin-l-imine derivatives by a simple three-component condensation of 2-cyanobenzaldhyde, ammonium acetate, and 4-hyroxycoumarin derivatives or 1,3-dicarbonyl compounds or 4-hydroxyquinolin-2(1H)-one in ethanol under reflux for 20-60 min with excellent yields. The advantages of this procedure are operational simplicity, excellent yields, and short reactive time, without catalyst, easy workup, and green environmental impact. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10933 / 10939
页数：7
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