Synthesis of uridine analogues to probe the functional group requirements of the hairpin ribozyme

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作者
Vyle, JS
Young, KJ
Jones, S
Grasby, JA
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中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
O-4-Methyluridine, O-2-methyluridine and (4H)uridine phosphoramidites were prepared with 2'-O-silyl protection, The methyl modified pyrimidines were synthesised from uridine via the triazolide (O-4-methyl) or 2,5'-cyclo derivative (O-2-methyl). An improved synthesis of protected 4-thiouridine was also performed.
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页码:S280 / S282
页数:3
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