Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

被引：12

作者：

Wandzik, Ilona ^{[1
]}

Bieg, Tadeusz ^{[1
]}

Czaplicka, Marianna ^{[2
]}

机构：

[1] Silesian Tech Univ, Fac Chem, Dept Organ Chem Bioorgan Chem & Biotechnol, PL-44100 Gliwice, Poland

[2] Inst Nonferrous Met, PL-4410 Gliwice, Poland

来源：

BIOORGANIC CHEMISTRY | 2009年 / 37卷 / 06期

关键词：

Glycosyltransferases; Donor substrate analogues; Glycals;

D O I：

10.1016/j.bioorg.2009.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine beta-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：211 / 216

页数：6

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