Reductive N-Arylethylation of Aromatic Amines and N-Heterocycles with Enol Ethers

被引：6
|
作者：
Voegerl, Katharina [1 ]
Ong, Duc Nghia [1 ]
Bracher, Franz [1 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Dept Pharm, Ctr Drug Res, Butenandtstr 5-13, D-81377 Munich, Germany
来源：
SYNTHESIS-STUTTGART | 2018年 / 50卷 / 06期
关键词：
arylethylation; triethylsilane; aromatic amines; heterocycles; chemoselectivity; TERTIARY-AMINES; ALKYLATION; AMINATION; INDOLES; DERIVATIVES; COMPLEXES; ALCOHOLS; SYSTEM; AGENTS; ACIDS;
D O I：
10.1055/s-0036-1591859
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient method for N-arylethylation of aromatic amines and heterocycles under mild reductive conditions was developed using (2-methoxyvinyl)(hetero)arenes as building blocks and triethylsilane/trifluoroacetic acid as reducing agent. This protocol is compatible with numerous functional groups, and aliphatic amines are inert due to protonation.
引用
收藏
页码：1323 / 1330
页数：8
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