Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

被引：120
|
作者：
Barton, Anne [1 ]
Thomson, Wendy [1 ]
Ke, Xiayi [1 ]
Eyre, Steve [1 ]
Hinks, Anne [1 ]
Bowes, John [1 ]
Plant, Darren [1 ]
Gibbons, Laura J. [1 ]
Wilson, Anthony G. [2 ]
Bax, Deborah E. [2 ]
Morgan, Ann W. [3 ]
Emery, Paul [3 ]
Steer, Sophia [4 ]
Hocking, Lynne [5 ]
Reid, David M. [5 ]
Wordsworth, Paul [6 ]
Harrison, Pille [6 ]
Worthington, Jane [1 ]
机构：
[1] Univ Manchester, Arthritis Res Campaign Epidemiol Unit, Manchester, Lancs, England
[2] Univ Sheffield, Sch Med & Biomed Sci, Sheffield S10 2JF, S Yorkshire, England
[3] Chapel Allerton Hosp, Acad Unit Musculoskeletal Dis, Leeds LS7 4SA, W Yorkshire, England
[4] Kings Coll Hosp London, Natl Hlth Serv Fdn Trust, London SE5 9RS, England
[5] Univ Aberdeen, Dept Med & Therapeut, Bone Res Grp, Aberdeen AB25 2ZD, Scotland
[6] Univ Oxford, Inst Musculoskeletal Sci, Botnar Res Ctr, Oxford OX3 7LD, England
来源：
NATURE GENETICS | 2008年 / 40卷 / 10期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
D O I：
10.1038/ng.218
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
引用
收藏
页码：1156 / 1159
页数：4
相关论文
共 50 条
  • [41] CHROMOSOME REARRANGEMENTS AT 12Q13 IN 2 CASES OF CHONDROSARCOMAS
    HIRABAYASHI, Y
    YOSHIDA, MA
    IKEUCHI, T
    ISHIDA, T
    KOJIMA, T
    HIGAKI, S
    MACHINAMI, R
    TONOMURA, A
    CANCER GENETICS AND CYTOGENETICS, 1992, 60 (01) : 35 - 40
  • [42] Identification of new translocation breakpoints at 12q13 in lipomas
    Merscher, S
    Marondel, I
    Pedeutour, F
    Gaudray, P
    Kucherlapati, R
    TurcCarel, C
    GENOMICS, 1997, 46 (01) : 70 - 77
  • [43] Framework for a physical map of the human 22q13 region using bacterial artificial chromosomes (BACs)
    Schmitt, H
    Kim, UJ
    Slepak, T
    Blin, N
    Simon, MI
    Shizuya, H
    GENOMICS, 1996, 33 (01) : 9 - 20
  • [44] Linkage analysis of genetic loci for kyphoscoliosis on chromosomes 5q13, 13q13.3, and 13q32
    Miller, NH
    Marosy, B
    Justice, CM
    Novak, SM
    Tang, EY
    Boyce, P
    Pettengil, J
    Doheny, KF
    Pugh, EW
    Wilson, AF
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2006, 140A (10) : 1059 - 1068
  • [45] A REARRANGEMENT BETWEEN CHROMOSOMAL REGIONS 12Q13-Q15 AND 14Q22-Q24, T(12-14)(Q13-15-Q22-24), MAY BE FOUND IN LEIOMYOMAS OF THE UTERUS
    HEIM, S
    NILBERT, M
    VANNI, R
    FLODERUS, UM
    MANDAHL, N
    LIEDGREN, S
    MITELMAN, F
    CYTOGENETICS AND CELL GENETICS, 1987, 46 (1-4): : 628 - 628
  • [46] Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families
    Auranen, M
    Nieminen, T
    Majuri, S
    Vanhala, R
    Peltonen, L
    Järvelä, I
    MOLECULAR PSYCHIATRY, 2000, 5 (03) : 320 - 322
  • [47] Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families
    M Auranen
    T Nieminen
    S Majuri
    R Vanhala
    L Peltonen
    I Järvelä
    Molecular Psychiatry, 2000, 5 : 320 - 322
  • [48] 22q13 deletion syndrome: An update and review for the primary pediatrician
    Havens, JM
    Visootsak, J
    Phelan, MC
    Graham, JM
    CLINICAL PEDIATRICS, 2004, 43 (01) : 43 - 53
  • [49] Overgrowth and retarded development associated with chromosome 22q13 deletion
    Hinkel, GK
    Bartsch, G
    Blin, N
    Friebel, D
    Klengel, S
    Kraft, S
    Schroder, K
    Werner, W
    MONATSSCHRIFT KINDERHEILKUNDE, 1997, 145 (09) : 892 - 896
  • [50] Sequence Variants at 22q13 Are Associated with Prostate Cancer Risk
    Sun, Jielin
    Zheng, Siqun Lilly
    Wiklund, Fredrik
    Isaacs, Sarah D.
    Li, Ge
    Wiley, Kathleen E.
    Kim, Seong-Tae
    Zhu, Yi
    Zhang, Zheng
    Hsu, Fang-Chi
    Turner, Aubrey R.
    Stattin, Par
    Liu, Wennuan
    Kim, Jin Woo
    Duggan, David
    Carpten, John
    Isaacs, William
    Gronberg, Henrik
    Xu, Jianfeng
    Chang, Bao-Li
    CANCER RESEARCH, 2009, 69 (01) : 10 - 15
12345