Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

被引：120

作者：

Barton, Anne ^{[1
]}

Thomson, Wendy ^{[1
]}

Ke, Xiayi ^{[1
]}

Eyre, Steve ^{[1
]}

Hinks, Anne ^{[1
]}

Bowes, John ^{[1
]}

Plant, Darren ^{[1
]}

Gibbons, Laura J. ^{[1
]}

Wilson, Anthony G. ^{[2
]}

Bax, Deborah E. ^{[2
]}

Morgan, Ann W. ^{[3
]}

Emery, Paul ^{[3
]}

Steer, Sophia ^{[4
]}

Hocking, Lynne ^{[5
]}

Reid, David M. ^{[5
]}

Wordsworth, Paul ^{[6
]}

Harrison, Pille ^{[6
]}

Worthington, Jane ^{[1
]}

机构：

[1] Univ Manchester, Arthritis Res Campaign Epidemiol Unit, Manchester, Lancs, England

[2] Univ Sheffield, Sch Med & Biomed Sci, Sheffield S10 2JF, S Yorkshire, England

[3] Chapel Allerton Hosp, Acad Unit Musculoskeletal Dis, Leeds LS7 4SA, W Yorkshire, England

[4] Kings Coll Hosp London, Natl Hlth Serv Fdn Trust, London SE5 9RS, England

[5] Univ Aberdeen, Dept Med & Therapeut, Bone Res Grp, Aberdeen AB25 2ZD, Scotland

[6] Univ Oxford, Inst Musculoskeletal Sci, Botnar Res Ctr, Oxford OX3 7LD, England

来源：

NATURE GENETICS | 2008年 / 40卷 / 10期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/ng.218

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

引用

页码：1156 / 1159

页数：4

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