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- [21] Discovery of a potent and highly selective, orally efficacious IKK2 inhibitor for the treatment of rheumatoid arthritisABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238Liddle, JohnWilliamson, Rick A.
- [22] Discovery of an Orally Efficacious Pyrazolo[3,4-d]pyrimidine Benzoxaborole as a Potent Inhibitor of CryptosporidiumJOURNAL OF MEDICINAL CHEMISTRY, 2024, 68 (01) : 832 - 849Gasonoo, MakafuiGuin, SoumitraTeixeira, Jose E.Oboh, EdmundGokanapalle, AnushaMiller, PeterOliva, JonathanSverdrup, Francis M.Huston, Christopher D.Meyers, Marvin J.
- [23] Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα)JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (23) : 20933 - 20965Rej, Rohan KalyanHu, BiaoChen, ZhixiangAcharyya, Ranjan KumarWu, DiminMetwally, HodaMceachern, DonnaWang, YuJiang, WeiBai, LongchuanNishimura, Leticia S.Gersch, Christina L.Wang, MeilinWen, BoSun, DuxinCarlson, KathrynKatzenellenbogen, John A.Xu, GuozhangZhang, WeihongWu, WenxuePriestley, E. ScottSui, ZhihuaRae, James M.Wang, Shaomeng
- [24] Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 HydrolaseJOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (23) : 16410 - 16425Thoma, GebhardMarkert, ChristianLueoend, RainerMiltz, WolfgangSpanka, CarstenBollbuck, BirgitWolf, Romain M.Srinivas, HonnappaPenno, Carlos A.Kiffe, MichaelGajewska, MonikaBednarczyk, DallasWieczorek, GrazynaEvans, AmandaBeerli, ChristianRohn, Till A.
- [25] Discovery of A-970781 as a potent, safe, and orally efficacious inhibitor of acyl CoA: Diacylglycerol acyltransferase 1ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243Kym, Philip R.Yeh, Vince C. S.Beno, David W. A.Brodjian, SevanBrune, Michael E.Cullen, Steven C.Dayton, Brian D.Dhaon, Madhup K.Falls, Hugh D.Gao, JuGrihalde, NelsonHajduk, Philip J.Hansen, T. MatthewJudd, Andrew S.King, Andrew J.Klix, Russell C.Larson, Kelly J.Lau, Yau Y.Marsh, Kennan C.Mittelstadt, Scott W.Plata, DanRozema, Michael J.Segreti, Jason A.Stoner, Eric J.Voorbach, Martin J.Wang, XiaojunXin, XiliZhao, GangCollins, Christine A.Cox, Bryan F.Reilly, Regina M.Souers, Andrew J.
- [26] Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (03) : 1337 - 1360Yang, YaxiZhang, RukangLi, ZhaojunMei, LiangheWan, ShiliDing, HongChen, ZhifengXing, JingFeng, HuijinHan, JieJiang, HualiangZheng, MingyueLuo, ChengZhou, Bing
- [27] Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 InhibitorJOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (06) : 1558 - 1568Birch, Alan M.Birtles, SusanBuckett, Linda K.Kemmitt, Paul D.Smith, Graham J.Smith, Tim J. D.Turnbull, Andrew V.Wang, Steven J. Y.
- [28] Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitorBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (20) : 6188 - 6194Liddle, JohnAtkinson, Francis L.Barker, Michael D.Carter, Paul S.Curtis, Neil R.Davis, Rob P.Douault, ClementDickson, Marion C.Elwes, DorothyGarton, Neil S.Gray, MatthewHayhow, Thomas G.Hobbs, Clare I.Jones, EmmaLeach, StuartLeavens, KarenLewis, Huw D.McCleary, ScottNeu, MargaretePatel, Vipulkumar K.Preston, Alex G. S.Ramirez-Molina, CesarShipley, Tracy J.Skone, Philip A.Smithers, NickSomers, Donald O.Walker, Ann L.Watson, Robert J.Weingarten, Gordon G.
- [29] Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (16) : 14125 - 14154Wang, ChangweiWang, MiWang, YuRej, Rohan KalyanAguilar, AngeloXu, TianfengBai, LongchuanTosovic, JelenaMcEachern, DonnaLi, QiuxiaSarkari, FarzadWen, BoSun, DuxinWang, Shaomeng
- [30] Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (17) : 5172 - 5175Semple, GraemeFioravanti, BeatrizPereira, GuillhermeCalderon, ImeldaUy, JaneChoi, KarolineXiong, YifengRen, AlbertMorgan, MichaelDave, VibhaThomsen, WilliamUnett, David J.Xing, CharlesBossie, StuartCarroll, ChrisChu, Zhi-LiangGrottick, Andrew J.Hauser, Erin K.Leonard, JamesJones, Robert M.