Cell-free chromatin: A newly described mediator of systemic inflammation

被引：4
|
作者：
Chaudhary, Shahid [1 ]
Mittra, Indraneel [1 ]
机构：
[1] Tata Mem Hosp, Translat Res Lab, Adv Ctr Treatment, Res & Educ Canc, Navi Mumbai 410210, India
来源：
JOURNAL OF BIOSCIENCES | 2019年 / 44卷 / 02期
关键词：
gamma H2AX; cell-free chromatin; double strand DNA breaks; inflammation; N kappa FB; systemic inflammation; FREE NUCLEIC-ACIDS; HEALTHY CELLS; DNA-DAMAGE; SENSOR; INDUCE; CGAS;
D O I：
10.1007/s12038-019-9849-7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recent research has shown that cell-free chromatin (cfCh) particles that are released from the billions of cells that die in the body everyday can enter into healthy cells, integrate into their genomes and induce dsDNA breaks and apoptotic responses. Genomic integration of cfCh activates NF kappa B suggesting a novel mechanism of induction of systemic inflammation. Since DNA damage and inflammation are underlying pathologies in multiple devastating acute and chronic disease conditions, the discovery of agents that can inactivate cfCh may provide therapeutic possibilities.
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页数：6
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