Cell-free chromatin: A newly described mediator of systemic inflammation

被引：4

作者：

Chaudhary, Shahid ^{[1
]}

Mittra, Indraneel ^{[1
]}

机构：

[1] Tata Mem Hosp, Translat Res Lab, Adv Ctr Treatment, Res & Educ Canc, Navi Mumbai 410210, India

来源：

JOURNAL OF BIOSCIENCES | 2019年 / 44卷 / 02期

关键词：

gamma H2AX; cell-free chromatin; double strand DNA breaks; inflammation; N kappa FB; systemic inflammation; FREE NUCLEIC-ACIDS; HEALTHY CELLS; DNA-DAMAGE; SENSOR; INDUCE; CGAS;

D O I：

10.1007/s12038-019-9849-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent research has shown that cell-free chromatin (cfCh) particles that are released from the billions of cells that die in the body everyday can enter into healthy cells, integrate into their genomes and induce dsDNA breaks and apoptotic responses. Genomic integration of cfCh activates NF kappa B suggesting a novel mechanism of induction of systemic inflammation. Since DNA damage and inflammation are underlying pathologies in multiple devastating acute and chronic disease conditions, the discovery of agents that can inactivate cfCh may provide therapeutic possibilities.

引用

页数：6

共 50 条

[21] INCORPORATION OF NEWLY SYNTHESIZED PROTEIN BY MYOFIBRILS IN A CELL-FREE SYSTEM
FISCHMAN, DA
BOUCHE, M
PENG, I
GOLDFINE, SM
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 1989, 10 (02) : 160 - 160
[22] Analysis of chromatin structural transitions in Drosophila embryo cell-free system
Kraevskii, VA
Prasolov, VS
DOKLADY AKADEMII NAUK, 1999, 365 (04) : 547 - 550
[23] Cell-free chromatin immunoprecipitation to detect molecular pathways in heart transplantation
Jang, Moon Kyoo
Markowitz, Tovah E.
Andargie, Temesgen E.
Apalara, Zainab
Kuhn, Skyler
Agbor-Enoh, Sean
LIFE SCIENCE ALLIANCE, 2023, 6 (12)
[24] Extracting regulatory active chromatin footprint from cell-free DNA
Lai, Kevin
Dilger, Katharine
Cunningham, Rachael
Lam, Kathy T.
Boquiren, Rhea
Truong, Khiet
Louie, Maggie C.
Rava, Richard
Abdueva, Diana
COMMUNICATIONS BIOLOGY, 2024, 7 (01)
[25] Chromatin accessibility patterns in cell-free DNA reveal tumor heterogeneity
Esfahani, Mohammad Shahrokh
Mehrmohamadi, Mahya
Steen, Chloe B.
Hamilton, Emily G.
King, Daniel A.
Soo, Joanne
Macaulay, Charles
Jin, Michael
Kurtz, David M.
Nabet, Barzin
Moding, Everett
Chabon, Jacob
Newman, Aaron
Diehn, Maximilian
Alizadeh, Ash A.
CANCER RESEARCH, 2020, 80 (16)
[26] Stability of normal and hyperaminoacetylated chromatin in cell-free system of Drosophila embryos
Kraevskii, VA
MOLECULAR BIOLOGY, 1999, 33 (05) : 659 - 665
[27] Analysis of chromatin conformational flexibility in drosophila embryo cell-free system
Kraevskii, VA
Prasolov, VS
DOKLADY AKADEMII NAUK, 1999, 365 (05) : 693 - 696
[28] Prevention of chemotherapy toxicity by agents that neutralize or degrade cell-free chromatin
Mittra, I.
Pal, K.
Pancholi, N.
Shaikh, A.
Rane, B.
Tidke, P.
Kirolikar, S.
Khare, N. K.
Agrawal, K.
Nagare, H.
Nair, N. K.
ANNALS OF ONCOLOGY, 2017, 28 (09) : 2119 - 2127
[29] Fragmentation of cell-free DNA is induced by upper-tract urothelial carcinoma-associated systemic inflammation
Nakano, Kosuke
Yamamoto, Yoshiyuki
Yamamichi, Gaku
Yumiba, Satoru
Tomiyama, Eisuke
Matsushita, Makoto
Koh, Yoko
Hayashi, Yujiro
Wang, Cong
Ishizuya, Yu
Kato, Taigo
Hatano, Koji
Kawashima, Atsunari
Ujike, Takeshi
Fujita, Kazutoshi
Nonomura, Norio
Uemura, Motohide
CANCER SCIENCE, 2021, 112 (01) : 168 - 177
[30] Brain-derived neurotrophic factor: A newly described mediator of angiogenesis
Kermani, Pouneh
Hempstead, Barbara
TRENDS IN CARDIOVASCULAR MEDICINE, 2007, 17 (04) : 134 - 140

← 1 2 3 4 5 →