Neural Stem Cells Harvested from Live Brains by Antibody-Conjugated Magnetic Nanoparticles

被引：17
|
作者：
Lui, C. N. P. [1 ]
Tsui, Y. P. [2 ,3 ]
Ho, A. S. L. [4 ]
Shum, D. K. Y. [2 ,3 ]
Chan, Y. S. [3 ,5 ]
Wu, C. T. [6 ]
Li, H. W. [4 ]
Tsang, S. C. Edman [6 ]
Yung, K. K. L. [1 ]
机构：
[1] Hong Kong Baptist Univ, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China
[2] Univ Hong Kong, LKS Fac Med, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, LKS Fac Med, Res Ctr Heart Brain Hormone & Hlth Aging, Hong Kong, Hong Kong, Peoples R China
[4] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
[5] Univ Hong Kong, LKS Fac Med, Dept Physiol, Hong Kong, Hong Kong, Peoples R China
[6] Univ Oxford, Dept Chem, Oxford OX1 3QR, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 47期
关键词：
antibodies; magnetic nanoparticles; nanoparticles; regenerative medicine; stem cells; SILICA NANOPARTICLES; PROGENITOR CELLS; IRON; NANOMAGNETS; FOREBRAIN; GRAFTS; RESCUE; MODEL;
D O I：
10.1002/anie.201305482
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12298 / 12302
页数：5
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