Neural Stem Cells Harvested from Live Brains by Antibody-Conjugated Magnetic Nanoparticles

被引：17
|
作者：
Lui, C. N. P. [1 ]
Tsui, Y. P. [2 ,3 ]
Ho, A. S. L. [4 ]
Shum, D. K. Y. [2 ,3 ]
Chan, Y. S. [3 ,5 ]
Wu, C. T. [6 ]
Li, H. W. [4 ]
Tsang, S. C. Edman [6 ]
Yung, K. K. L. [1 ]
机构：
[1] Hong Kong Baptist Univ, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China
[2] Univ Hong Kong, LKS Fac Med, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, LKS Fac Med, Res Ctr Heart Brain Hormone & Hlth Aging, Hong Kong, Hong Kong, Peoples R China
[4] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
[5] Univ Hong Kong, LKS Fac Med, Dept Physiol, Hong Kong, Hong Kong, Peoples R China
[6] Univ Oxford, Dept Chem, Oxford OX1 3QR, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 47期
关键词：
antibodies; magnetic nanoparticles; nanoparticles; regenerative medicine; stem cells; SILICA NANOPARTICLES; PROGENITOR CELLS; IRON; NANOMAGNETS; FOREBRAIN; GRAFTS; RESCUE; MODEL;
D O I：
10.1002/anie.201305482
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12298 / 12302
页数：5
相关论文
共 50 条
  • [21] Fabrication of Oriented Antibody-Conjugated Magnetic Nanoprobes and Their Immunoaffinity Application
    Lin, Po-Chiao
    Chen, Shu-Hua
    Wang, Kai-Yi
    Chen, Mu-Lin
    Adak, Avijit Kumar
    Hwu, Jih-Ru R.
    Chen, Yu-Ju
    Lin, Chun-Cheng
    ANALYTICAL CHEMISTRY, 2009, 81 (21) : 8774 - 8782
  • [22] CD133 antibody-conjugated immunoliposomes encapsulating gemcitabine for targeting glioblastoma stem cells
    Shin, Dae Hwan
    Xuan, Shuhua
    Kim, Woo-Young
    Bae, Gyu-Un
    Kim, Jin-Seok
    JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (24) : 3771 - 3781
  • [23] Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics
    Kumari, Mamta
    Acharya, Amitabha
    Krishnamurthy, Praveen Thaggikuppe
    BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 2023, 14 : 912 - 926
  • [24] Targeting Colorectal Cancer Stem-Like Cells with Anti-CD133 Antibody-Conjugated SN-38 Nanoparticles
    Ning, Sin-Tzu
    Lee, Shin-Yu
    Wei, Ming-Feng
    Peng, Cheng-Liang
    Lin, Susan Yun-Fan
    Tsai, Ming-Hsien
    Lee, Pei-Chi
    Shih, Ying-Hsia
    Lin, Chun-Yen
    Luo, Tsai-Yueh
    Shieh, Ming-Jium
    ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (28) : 17793 - 17804
  • [25] Antibody-Conjugated Barium Titanate Nanoparticles for Cell-Specific Targeting
    Jordan, Tomas
    O'Brien, Mikaela A.
    Spatarelu, Catalina
    Luke, Geoffrey P.
    ACS APPLIED NANO MATERIALS, 2020, 3 (03): : 2636 - 2646
  • [26] Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells
    Kagawa, Tetsuya
    Matsumi, Yuki
    Aono, Hiromichi
    Ohara, Toshiaki
    Tazawa, Hiroshi
    Shigeyasu, Kunitoshi
    Yano, Shuya
    Takeda, Sho
    Komatsu, Yasuhiro
    Hoffman, Robert M.
    Fujiwara, Toshiyoshi
    Kishimoto, Hiroyuki
    CELL CYCLE, 2021, 20 (13) : 1221 - 1230
  • [27] Antibody-conjugated magnetoliposomes for targeting cancer cells and their application in hypothermia
    Shinkai, M.
    Suzuki, M.
    Iijima, S.
    Kobayashi, T.
    Biotechnology and Applied Biochemistry, 1600, 21 (02):
  • [28] IMAGING, TARGETED THERAPY, AND IDENTIFICATION OF CANDIDATE PROTEINS OF GLIOMA STEM CELLS. EGFRVIII ANTIBODY-CONJUGATED MAGNETIC NANOPARTICLES INHIBIT FORMATION AND PROLIFERATION OF GBM-DERIVED NEUROSPHERES
    Kaluzova, Milota
    Machaidze, Revaz
    Nduom, Edjah Nduom K.
    Burden, Carol T.
    Hadjipanayis, Costas G.
    NEURO-ONCOLOGY, 2010, 12 : 125 - 125
  • [29] HAI-178 antibody-conjugated fluorescent magnetic nanoparticles for targeted imaging and simultaneous therapy of gastric cancer
    Can Wang
    Chenchen Bao
    Shujing Liang
    Lingxia Zhang
    Hualin Fu
    Yutian Wang
    Kan Wang
    Chao Li
    Min Deng
    Qiande Liao
    Jian Ni
    Daxiang Cui
    Nanoscale Research Letters, 9
  • [30] Negative selection of murine neutrophils from whole blood using antibody-conjugated magnetic beads
    Cotter, MJ
    Norman, KE
    Hellewell, PG
    Ridger, VC
    FASEB JOURNAL, 2000, 14 (04): : A785 - A785
12345