Synthesis of 6-(5-Methylisoxazol-3yl)-3-alkyl Sulfanyl-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazoles

被引：4

作者：

Vaarla, Krishnaiah ^{[1
]}

Vedula, Rajeswar Rao ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Warangal 506004, Andhra Pradesh, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 06期

关键词：

PHARMACOLOGICAL-ACTIVITIES; HETEROCYCLIC SYSTEM; BIOLOGICAL-ACTIVITY; DERIVATIVES; AGENTS; ANTICANCER;

D O I：

10.1002/jhet.2168

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of isoxazole substituted fused triazolo-thiadiazoles have been synthesized by the cyclocondensation of 5-methylisoxazole-3-craboxylic acid and 4-amino 1,2-4-triazole- 3,5-dithiol using phosphorous oxychloride. The cyclised intermediate 6-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-3-thiol later on S-alkylated with different alkyl halides in ethanol to give the title products in good to excellent yields.

引用

页码：1614 / 1617

页数：4

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