Synthesis of 6-(5-Methylisoxazol-3yl)-3-alkyl Sulfanyl-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazoles

被引：4
|
作者：
Vaarla, Krishnaiah [1 ]
Vedula, Rajeswar Rao [1 ]
机构：
[1] Natl Inst Technol, Dept Chem, Warangal 506004, Andhra Pradesh, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 06期
关键词：
PHARMACOLOGICAL-ACTIVITIES; HETEROCYCLIC SYSTEM; BIOLOGICAL-ACTIVITY; DERIVATIVES; AGENTS; ANTICANCER;
D O I：
10.1002/jhet.2168
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new series of isoxazole substituted fused triazolo-thiadiazoles have been synthesized by the cyclocondensation of 5-methylisoxazole-3-craboxylic acid and 4-amino 1,2-4-triazole- 3,5-dithiol using phosphorous oxychloride. The cyclised intermediate 6-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-3-thiol later on S-alkylated with different alkyl halides in ethanol to give the title products in good to excellent yields.
引用
收藏
页码：1614 / 1617
页数：4
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