One-Pot Anti-Markovnikov Hydroamination of Unactivated Alkenes by Hydrozirconation and Amination

被引：63
|
作者：
Strom, Alexandra E. [1 ]
Hartwig, John F. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 17期
关键词：
COPPER-CATALYZED AMINATION; CONVENIENT SYNTHESIS; ORGANIC AZIDES; STEREOSPECIFIC SYNTHESIS; SECONDARY-AMINES; FACILE REACTION; ORGANOBORANES; CHLORAMINE; ALKYL; DIMETHYLALKYLBORANES;
D O I：
10.1021/jo401498w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.
引用
收藏
页码：8909 / 8914
页数：6
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