One-Pot Anti-Markovnikov Hydroamination of Unactivated Alkenes by Hydrozirconation and Amination

被引：63

作者：

Strom, Alexandra E. ^{[1
]}

Hartwig, John F. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 17期

关键词：

COPPER-CATALYZED AMINATION; CONVENIENT SYNTHESIS; ORGANIC AZIDES; STEREOSPECIFIC SYNTHESIS; SECONDARY-AMINES; FACILE REACTION; ORGANOBORANES; CHLORAMINE; ALKYL; DIMETHYLALKYLBORANES;

D O I：

10.1021/jo401498w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.

引用

页码：8909 / 8914

页数：6

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