Heart rate reduction in heart failure: ivabradine or beta blockers?

被引：5
|
作者：
Guglin, Maya [1 ]
机构：
[1] Univ S Florida, Dept Med, Tampa, FL 33620 USA
来源：
HEART FAILURE REVIEWS | 2013年 / 18卷 / 04期
关键词：
Ivabradine; Heart rate; Beta blockers; Heart failure; Vagal stimulation; LEFT-VENTRICULAR DYSFUNCTION; I-F INHIBITOR; PLACEBO-CONTROLLED TRIAL; CORONARY-ARTERY-DISEASE; CHRONIC STABLE ANGINA; QUALITY-OF-LIFE; SYSTOLIC DYSFUNCTION; DOUBLE-BLIND; POSTMYOCARDIAL INFARCTION; EXERCISE CAPACITY;
D O I：
10.1007/s10741-012-9347-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ivabradine, a selective I f current inhibitor, decreasing the heart rate in those with sinus rhythm, has been added to the most recent European guidelines on heart failure. It is indicated in addition to beta blockers in patients with decreased left ventricular ejection fraction and sinus rate of over 70 beats per minute. Several well-designed studies including the BEAUTIFUL and the SHIFT trials demonstrated clear benefits of ivabradine in symptomatic patients, both with angina and with heart failure, with left ventricular systolic dysfunction. The main objective of this review is to provide a comprehensive summary of data on ivabradine, and to discuss the potential role of this new agent in the spectrum of modern therapeutics for heart failure.
引用
收藏
页码：517 / 528
页数：12
相关论文
共 50 条
  • [31] Beta-Blockers and Ivabradine in Chronic Heart Failure: From Clinical Trials to Clinical Practice
    Di Franco, Antonino
    Sarullo, Filippo M.
    Salerno, Ylenia
    Figliozzi, Stefano
    Parrinello, Rossella
    Di Pasquale, Pietro
    Lanza, Gaetano A.
    AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2014, 14 (02) : 101 - 110
  • [32] Beta blockers and congestive heart failure
    Movahed, A
    AMERICAN FAMILY PHYSICIAN, 2000, 62 (11) : 2402 - 2404
  • [33] Beta-blockers in heart failure
    Cohn, JN
    EUROPEAN HEART JOURNAL, 1998, 19 : F52 - F55
  • [34] Prescription of beta blockers in heart failure
    Perez Calvo, J. Ignacio
    Amores Arriaga, B.
    Torralba Cabeza, M. A.
    REVISTA CLINICA ESPANOLA, 2008, 208 (02): : 111 - 112
  • [35] Beta blockers in systolic heart failure
    Jackowski, Leslie
    Azam, Roshmeen
    AUSTRALIAN FAMILY PHYSICIAN, 2008, 37 (03) : 137 - 139
  • [36] Beta-blockers in heart failure
    Yudkin, J
    DIABETIC MEDICINE, 1999, 16 (09) : 785 - 787
  • [37] Innovation in coronary artery disease and heart failure: clinical benefits of pure heart rate reduction with ivabradine
    Canet, Emmanuel
    Lerebours, Guy
    Vilaine, Jean-Paul
    PHARMACEUTICAL SCIENCE TO IMPROVE THE HUMAN CONDITION: WINNERS AND FINALIST CANDIDATES OF THE PRIX GALIEN USA, INTERNATIONAL, AND PRO BONO HUMANITARIAN AWARDS 2010, 2011, 1222 : 90 - 99
  • [38] Heart rate reduction strategy with ivabradine is effective in reducing acute heart failure in duchenne dilated cardiomyopathy
    Adorisio, R.
    Cantarutti, N.
    D'Amico, A.
    Chinali, M.
    Baban, A.
    Iorio, F. S.
    Amodeo, A.
    Drago, F.
    EUROPEAN HEART JOURNAL, 2017, 38 : 1105 - 1105
  • [39] Heart rate reduction and improvement of NYHA class during uptitration of beta-blockers for heart failure independently predict mortality
    Duengen, H. -D.
    Inkrot, S.
    Tahirovic, E.
    Trippel, T. D.
    Tscholl, V.
    Obradovic, D.
    Matic, D.
    Putnikovic, B.
    Haverkamp, W.
    Gelbrich, G.
    EUROPEAN HEART JOURNAL, 2012, 33 : 483 - 483
  • [40] Heart rate reduction and improvement of NYHA class during uptitration of beta-blockers for heart failure independently predict mortality
    Duengen, H-D.
    Inkrot, S.
    Tahirovic, E.
    Musial-Bright, L.
    Trippel, T.
    Tscholl, V.
    Krackhardt, F.
    Haverkamp, W.
    Apostolovic, S.
    Gelbrich, G.
    EUROPEAN JOURNAL OF HEART FAILURE, 2013, 12 : S179 - S179
12345