Heart rate reduction in heart failure: ivabradine or beta blockers?

被引：5
|
作者：
Guglin, Maya [1 ]
机构：
[1] Univ S Florida, Dept Med, Tampa, FL 33620 USA
来源：
HEART FAILURE REVIEWS | 2013年 / 18卷 / 04期
关键词：
Ivabradine; Heart rate; Beta blockers; Heart failure; Vagal stimulation; LEFT-VENTRICULAR DYSFUNCTION; I-F INHIBITOR; PLACEBO-CONTROLLED TRIAL; CORONARY-ARTERY-DISEASE; CHRONIC STABLE ANGINA; QUALITY-OF-LIFE; SYSTOLIC DYSFUNCTION; DOUBLE-BLIND; POSTMYOCARDIAL INFARCTION; EXERCISE CAPACITY;
D O I：
10.1007/s10741-012-9347-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ivabradine, a selective I f current inhibitor, decreasing the heart rate in those with sinus rhythm, has been added to the most recent European guidelines on heart failure. It is indicated in addition to beta blockers in patients with decreased left ventricular ejection fraction and sinus rate of over 70 beats per minute. Several well-designed studies including the BEAUTIFUL and the SHIFT trials demonstrated clear benefits of ivabradine in symptomatic patients, both with angina and with heart failure, with left ventricular systolic dysfunction. The main objective of this review is to provide a comprehensive summary of data on ivabradine, and to discuss the potential role of this new agent in the spectrum of modern therapeutics for heart failure.
引用
收藏
页码：517 / 528
页数：12
相关论文
共 50 条
  • [21] Time to benefit of heart rate reduction with ivabradine in patients with heart failure and reduced ejection fraction
    Boehm, Michael
    Abdin, Amr
    Slawik, Jonathan
    Mahfoud, Felix
    Borer, Jeffrey
    Ford, Ian
    Swedberg, Karl
    Tavazzi, Luigi
    Batailler, Cecile
    Komajda, Michel
    EUROPEAN JOURNAL OF HEART FAILURE, 2023, : 1429 - 1435
  • [22] Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure
    De Ferrari, Gaetano M.
    Mazzuero, Antonio
    Agnesina, Laura
    Bertoletti, Alessandra
    Lettino, Maddalena
    Campana, Carlo
    Schwartz, Peter J.
    Tavazzi, Luigi
    EUROPEAN JOURNAL OF HEART FAILURE, 2008, 10 (06) : 550 - 555
  • [23] Effects on Outcomes of Heart Rate Reduction by Ivabradine in Patients With Congestive Heart Failure: Is There an Influence of Beta-Blocker Dose? Findings From the SHIFT (Systolic Heart failure treatment with the If inhibitor ivabradine Trial) Study
    Swedberg, Karl
    Komajda, Michel
    Boehm, Michael
    Borer, Jeffrey
    Robertson, Michele
    Tavazzi, Luigi
    Ford, Ian
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (22) : 1938 - 1945
  • [24] Effects of ivabradine plus beta blockers as first step therapy on heart rate, compliance, quality of life and exercise tolerance in patients with chronic heart failure
    Macchi, A.
    Franzoni, I.
    Rosa, I.
    Pedrigi, M. C.
    Buzzetti, F.
    Gorla, R.
    Gaudio, G. V.
    Camici, P. G.
    Margonato, A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 : 641 - 642
  • [25] Effects of ivabradine plus beta blockers as first step therapy on heart rate, compliance, quality of life and exercise tolerance in patients with chronic heart failure
    Macchi, A.
    Franzoni, I.
    Rosa, I.
    Pedrigi, M. C.
    Buzzetti, F.
    Gorla, R.
    Gaudio, G. V.
    Camici, P. G.
    Margonato, A.
    EUROPEAN HEART JOURNAL, 2011, 32 : 641 - 642
  • [26] Heart Rate Reduction by Ivabradine: Slowly but Surely?
    Kojonazarov, Baktybek
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2020, 63 (06) : 725 - 726
  • [27] THE DIFFERENT DEGREES OF THE HEART RATE REDUCTION INDUCED BY β-BLOCKERS THERAPY ON RATS WITH HEART FAILURE
    Yin Nana
    Peng Yingxin
    JOURNAL OF HYPERTENSION, 2018, 36 : E58 - E58
  • [28] Ivabradine: Cardioprotection By and Beyond Heart Rate Reduction
    Gerd Heusch
    Petra Kleinbongard
    Drugs, 2016, 76 : 733 - 740
  • [29] Ivabradine: Cardioprotection By and Beyond Heart Rate Reduction
    Heusch, Gerd
    Kleinbongard, Petra
    DRUGS, 2016, 76 (07) : 733 - 740
  • [30] Beta-Blockers and Ivabradine in Chronic Heart Failure: From Clinical Trials to Clinical Practice
    Antonino Di Franco
    Filippo M. Sarullo
    Ylenia Salerno
    Stefano Figliozzi
    Rossella Parrinello
    Pietro Di Pasquale
    Gaetano A. Lanza
    American Journal of Cardiovascular Drugs, 2014, 14 : 101 - 110
12345