Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

被引：4

作者：

Kossakowski, Jerzy ^{[1
]}

Bielenica, Anna ^{[1
]}

Struga, Marta ^{[1
]}

Koziol, Anna E. ^{[2
]}

机构：

[1] Med Univ Warsaw, Dept Med Chem, PL-02007 Warsaw, Poland

[2] Marie Curie Sklodowska Univ, Fac Chem, PL-20031 Lublin, Poland

来源：

MEDICINAL CHEMISTRY RESEARCH | 2008年 / 17卷 / 08期

关键词：

cyclic imide derivative; N-phenylpiperazine derivative; 5HT(1A) and 5HT(2A) receptor affinity;

D O I：

10.1007/s00044-008-9094-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and pharmacological activity of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione is described. The structure of the compound was confirmed by elemental analysis, (1)H nuclear magnetic resonance (NMR), (13)C NMR, mass spectra, and X-ray crystallography. The compound exhibited significant affinity to both 5-HT(1A) and 5-HT(2A) receptors, similarly to aripiprazole, which is an atypical antipsychotic drug.

引用

页码：507 / 514

页数：8

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