Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

被引：4
|
作者：
Kossakowski, Jerzy [1 ]
Bielenica, Anna [1 ]
Struga, Marta [1 ]
Koziol, Anna E. [2 ]
机构：
[1] Med Univ Warsaw, Dept Med Chem, PL-02007 Warsaw, Poland
[2] Marie Curie Sklodowska Univ, Fac Chem, PL-20031 Lublin, Poland
来源：
MEDICINAL CHEMISTRY RESEARCH | 2008年 / 17卷 / 08期
关键词：
cyclic imide derivative; N-phenylpiperazine derivative; 5HT(1A) and 5HT(2A) receptor affinity;
D O I：
10.1007/s00044-008-9094-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and pharmacological activity of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione is described. The structure of the compound was confirmed by elemental analysis, (1)H nuclear magnetic resonance (NMR), (13)C NMR, mass spectra, and X-ray crystallography. The compound exhibited significant affinity to both 5-HT(1A) and 5-HT(2A) receptors, similarly to aripiprazole, which is an atypical antipsychotic drug.
引用
收藏
页码：507 / 514
页数：8
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