Molecular pathogenesis of the Antiphospholipid syndrome

被引：94
|
作者：
Rand, JH [1 ]
机构：
[1] Mt Sinai Sch Med, Div Hematol, Dept Med, Thrombosis & Hemostasis Sect, New York, NY 10029 USA
来源：
CIRCULATION RESEARCH | 2002年 / 90卷 / 01期
关键词：
antiphospholipid antibodies; anticardiolipin antibodies; lupus anticoagulants; thrombosis; annexins;
D O I：
10.1161/hh0102.102795
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The antiphospholipid (aPL) syndrome is an acquired autoimmune disorder of unknown etiology in which patients present with thrombosis together with laboratory evidence for antibodies in blood that recognize anionic phospholipid-protein complexes. The main antigenic target for the aPL antibodies has been identified to be beta(2) glycoprotein I (beta(2)GPI), a phospholipid-binding protein. The high affinity of aPL antibody-beta(2)GPI complex for phospholipid membranes seems to be a critical step in the mechanism of this disease. This review focuses on some of the major mechanisms that have been proposed to explain this disorder.
引用
收藏
页码：29 / 37
页数：9
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